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Title : Dr.
First Name : ALBA
University/Institution : University of Miami Miller School of Medicine
Phone # : 786-901-3324
Email ID : axt809@miami.edu
City : Miami
Country : United States
State : Florida
Zipcode : 33136
Department : Neurology
Company Name :
Area of Research
Mitochondrial diseases
Area of Expertise
Molecular Biology
Brief Description of Research Interest :
My long-term research interests involve the understanding of key pathways in mitochondrial biogenesis and how their alterations contribute to human neuromuscular disease, as a prerequisite for the development of therapeutic approaches. My academic training and undergraduate research experience have provided me with an excellent background in multiple biological disciplines, such as molecular biology, biochemistry, genetics, and translational research; and with valuable skills, including public speaking, literature analysis, and biomedical ethics. I have also received several academic awards and fellowships to support my studies and career. 
During my graduate studies, 
I was able to conduct research on the mitochondrial adaptations to stress, which resulted in two first author publications. My PhD studies have efficiently trained me with several molecular,biochemical and microbiological techniques, as well as bioinformatics and statistics. This experience was fundamental to develop my interest in mitochondrial plasticity and biogenesisTherefore, for my postdoctoral training, I have continued to build on my previous training by moving into a mammalian system that has allowed me to address additional questions regarding disease mechanisms. My project aim is to gain insight into the role of two hypoxia-inducible proteins in the assembly of mitochondrial respiratory chain complexes and supercomplexes in different nutritional and environmental conditions. 
Representative Publications :

Timón-Gómez, A.,Garlich, J., Stuart, R., Ugalde, C., Barrientos, A. (2019). Mitochondrial HIGD1A and HIGD2A have independent and overlapping cooperative functions in the biogenesis and organization of respiratory chain complexes. Molecular Cell. Submitted.

Lobo-Jarne, T.#, Pérez-Pérez, R.#,Fontanesi, F., Timón-Gómez, A., Wittig, I., Penas, A., García-Consuegra,I., Arenas, J., Martín, M.A., Barrientos, A., Ugalde, C. (2019). Multiple pathways coordinate human mitochondrial complex IV assembly and the stability of respiratory super complexes. Molecular Cell. Submitted.

Lobo-Jarne, T.#, Nyvltova,E.#, Pérez-Pérez, R., Timón-Gómez, A., Molinie, T., Choi, A.,Mourier, A., Fontanesi, F., Ugalde, C., Barrientos. A. (2018). Mitochondrial COX7A2L regulates complex III biogenesis and promotes super complex organization remodeling without affecting mitochondrial bioenergetics. Cell Reports, 25(7):1786-1799.e4. doi: 10.1016/j.celrep.2018.10.058.

Timón-Gómez, A., Proft, M.,Pascual-Ahuir, A. (2018). Selective degradation of yeast respiratory chain complexes by mitophagy upon stress. Journal of Biological Chemistry. Writing process. 

Timón-Gómez,A.#, Nyvltova, E.#, Abriata,L.A., Hosler, J., Barrientos, A. (2018). Human cytochrome c oxidase biogenesis: recent developments. Review. Seminars in Cell Biology and Development. Submitted.#Equal contribution.

Pascual-Ahuir,A., Manzanares-Estreder, S., Timón-Gómez, A., Proft, M. (2018). Ask yeast how to burn your fats: Lessons learned from the metabolic adaptation to salt stress. Minireview. Current Genetics. [Epub ahead to print].

Timón-Gómez A, Proft M,Pascual-Ahuir A (2013). Differential Regulation of Mitochondrial Pyruvate Carrier Genes Modulates Respiratory Capacity and Stress Tolerance in Yeast. PLoS ONE 8(11): e79405. doi:10.1371/journal.pone.0079405.