I'm a human immunologist interested in understanding the complexity of cell-cell communication using mathematical modeling to address system's level question in different types of diseases : cancer, allergy and inflammatory disorders/auto-immunity

My primary expertise is cellular biology of human dendritic cells, including dendritic cell subsets and response to exogeneous and endogeneous stimulation, I have deeply studied how different type of dendritic cells would induce the differentiation of distinct effector subsets of CD4 T cells, namely Th1, Th2, Th17 and Treg

I applied knowledge from this primary expertise to the study of various diseases using ex-vivo tissues or in-vitro models (patient derived organoids) such as Atopic dermatitis, Auto-immune disorders, Cancers (Breast, Ovarian, Head and Neck, Colorectal) integrating large scale datasets such as transcriptomic and genomics but also large scale perturbative screens in co-culture models in order to discover novel communication mechanisms and to question the mode of action of drugs, their specificity and potential interactions

Trichot C, Faucheux L, Karpf L, Grandclaudon M, Pattarini L, Bagot M, Mahévas T, Jachiet M, Saussine A, Bouaziz JD, Soumelis V. Th cell diversity and response to dupilumab in patients with atopic dermatitis. JACI 2020

Grandclaudon M* , Perrot-Dockes M*, Trichot C*, Abou-Jaoudé W, Hupé P, Thieffry D, Chiquet J, Levy-Leduc C, Soumelis V. A quantitative multivariate model of human dendritic cell-T helper cell communication. Cell 2019

Faucheux L*, Grandclaudon M*, Perrot-Dockes M*, Sirven P, Berger F, Vincent-Salomon A, Mechta-Grigoriou F, Scholer-Dahirel A, Soumelis V. A multivariate Th17 metagene for prognostic stratification in T cell non-inflamed triple negative breast cancer. OncoImmunology 2019

Pattarini L, Trichot C, Bogiatzi S, Grandclaudon M, Meller S, Keuylian Z, Durand M, Volpe E, Madonna S, Cavani A, Chiricozzi A, Romanelli M, Hori T, Hovnanian A, Homey B, and Soumelis V. TSLP-activated dendritic cells induce human T follicular helper cell differentiation through OX40-ligand. J Exp Med 2017

Abou-Jaoudé W, Monteiro PT, Naldi A, Grandclaudon M, Soumelis V, Chaouiya C, Thieffry D. Model checking to assess T- helper cell plasticity. Front Bioeng Biotechnol 2015

Martínez-Cingolani C, Grandclaudon M, Jeanmougin M, Jouve M, Zollinger R,Soumelis V. Human blood BDCA-1 dendritic cells differentiate into Langerhans-like cells with thymic stromal lymphopoietin and TGF-β. Blood 2014