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  Dr. LIN SONG  
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Title : Dr.
First Name : LIN
Last Name : SONG
University/Institution : University California, San Francisco
Email ID : lin.song@ucsf.edu
City : San Francisco
Country : United States
State : California
Zipcode : 94107
Department : School of medicine
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Area of Research
lung cancer
Area of Expertise
Cancer genomic, mouse models, cancer biology,laboratory medicine, pathology
Brief Description of Research Interest :

Trained oringally as a medical pathologist, I am a biomedical researcher with a Ph.D. in biochemistry with a specific interest in the genomics of lung cancer.  In the laboratory, I am using a variety of techniques to investigate the biology and clinical behavior of lung cancer. In particular, I am using a combination of genetically engineered mouse models, cell lines to interrogate multiple genomic outputs from clinical data. I am developing new mouse models of lung cancer to model somatic events, which is related to mutations in patient genomes.  I am working on the system to mimic overexpression of wt alleles and silencing or destruction of endogenous genes using CRISPR techniques, which have modified for in vivo use. I have combined mice has flox insertion with lentivirus packaged plasmid to create more complex system to achieve both silencing and overexpression a number of genes at same time.  

Representative Publications :

 Expression of N471D strumpellin leads to defects in the endolysosomal system. Dis Model Mech. 2018 09 13; 11(9). Song L, Rijal R, Karow M, Stumpf M, Hahn O, Park L, Insall R, Schröder R, Hofmann A, Clemen CS, Eichinger L. PMID: 30061306.

Galectin-3 in cancer. Clin Chim Acta. 2014 Apr 20; 431:185-91. Song L, Tang JW, Owusu L, Sun MZ, Wu J, Zhang J. PMID: 24530298.  Annexin A7 and its binding protein galectin-3 influence mouse hepatocellular carcinoma cell line in vitro. Biomed Pharmacother. 2014 Apr; 68(3):377-84. Song L, Mao J, Zhang J, Ibrahim MM, Li LH, Tang JW. PMID: 24373698.

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