First Name
Last Name
University of Pittsburgh
Email ID
United States
Zip code
Physical Medicine and Rehabilitation
Area of Research
Aging, Skeletal muscle, Stem cells, Rehabiliation sciences, Regenerative Medicine, Extracellular vesicles
Area of Expertise
Brief Description of Research Interest:

My long term research interest lies in developing precise rehabilitation strategies to enhance age-related declines in skeletal muscle and cognitive function. I use both pre-clinical and clinical models to elucidate the molecular mechanisms underlying the beneficial effects of exercise on skeletal muscle vitality and cognitive capacity, in a geriatric population. 


Currently, I am investigating the role circulating anti-geronic factors on improving skeletal muscle health and regenerative capacity of a geriatric population, in response to muscle specific resistance training protocols. In particular, I am interested in identifying mechanisms through which a pro-longevity protein called Klotho improves both, skeletal muscle regenerative capacity and cognition in an aging population. Additionally, my research focus includes studying the role of extracellular vesicles as a means to mediating such beneficial effects exercise on skeletal functional capacity and cognition of an aging population.

Representative Publications:

Sahu A, Mamiya H,Shinde SN, Cheikhi A, Winter LL, Vo NV, Stolz D, Roginskaya V, Tang WY, St Croix C, Sanders LH, Franti M, Van Houten B, Rando TA, Barchowsky A, Ambrosio F. Age-related declines in α-Klotho drive progenitor cell mitochondrial dysfunction and impaired muscle regeneration. Nat Commun. 2018 Nov 19; 9(1):4859. 

Anguiano T, Sahu A, Qian B, Tang WY, Ambrosio  F, Barchowsky A. Arsenic Directs Stem Cell Fate by Imparting Notch Signaling into the Extracellular Matrix Niche. Toxicol Sci. Accepted. 2020 July 09; PubMed PMID: 32647881

Sachdev U, Ferrari R, Cui X, Pius A, Sahu A,Reynolds M, Liao H, Sun P, Shinde S, Ambrosio F, Shiva S, Loughran P, Scott M. Caspase1/11 signaling affects muscle regeneration and recovery following ischemia, and can be modulated by chloroquine. Version 2. Mol Med. 2020 Jul8;26(1):69. doi: 10.1186/s10020-020-00190-2. PMID: 32641037; PMCID: PMC7341481.


Pius A*, Clemens Z*, Sivakumar S*, Sahu A, Shinde SN, Mamiya H, Luketich N, Cui J, Hoeck J,Kreuz  S, Franti M, Barchowsky A,Ambrosio F. The biphasic and age-dependent impact of Klotho on hallmarks ofaging and skeletal muscle function. bioRxiv. 2020 July 22; doi: https://doi.org/10.1101/2020.07.22.207043.*contributed equally

Palchesko RN*, Szymanski JM*, Sahu A*, Feinberg AW. Shrink Wrapping Cells in a Defined Extracellular Matrix to Modulate the Chemo-Mechanical Microenvironment. Cell Mol Bioeng. 2014 Sep;7(3):355-368. PubMed PMID: 25530816; PubMed Central PMCID: PMC4266992.*contributed equally