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Title : Dr.
First Name : KATHRIN
University/Institution : University of Urbana-Champaign
Email ID : kathrin.bohn@googlemail.com
City : Urbana
Country : United States
State : Illinois
Zipcode : 61801
Department : Bioengineering
Company Name :
Area of Research
HIV latency,Fluctuations in mouse embryonic stem cells, Herpes simplex virus resistance to antiviral drugs
Area of Expertise
Antivirale resistance testing, Host-virus relationship
Brief Description of Research Interest :
In my doctoral research work at the Institute of Virology and Antiviral Therapie in Germany, I investigated the development of antiviral resistance in clinical Herpes-simplex virus type 1 and 2 (HSV-1/2) strains and developed a database about important resistance mutations and single nucleotide polymorphisms in the viral thymidine kinase and DNA polymerase of available for all clinical physicians.  

My current research work focus on understanding how fluctuations in gene expression have an influence on pluripotency in mouse embryonic stem cells.

My long term research interest involve the interaction of the HIV virus with its host cell and how the virus adapted to the host cell. My previous research has shown that an increase of host cell size is sufficient to reactivate HIV from latency and that reactivate HIV-infected T-cells are able to slow down their migration speed due to expression of the viral Tat protein. Investigations of viral-host relationship are necessary to improve therapeutic strategies.
Representative Publications :

Bohn-Wippert K*, Tevonian EN*, Lu Y, Huang M-Y, Megaridis MR, Dar RD (2018). "Cell-size based decision-making of a viral gene circuit.“ Cell Reports 25:3844-3857.

Megaridis MR, Lu Y, Tevonian EN, Junger KM, Moy J, Bohn-Wippert K, Dar RD (2018). “Fine-tuning of noise in gene expression with nucleosome remodeling.” APL Bioengineering2:026106.

Bohn-Wippert K, Tevonian EN, Megaridis MR, Dar RD (2017). “Similarity in viral and host promoters couples viral reactivation with host cell migration.” Nature Communications 8:15006.

Sauerbrei A, Bohn-Wippert K, Kaspar M, Krumbholz Andi, Karrasch M, Zell R(2016)“Database on natural polymorphisms and resistance-related non-synonymous mutations in thymidine kinase and DNA polymerase genes of herpes simplex virus types 1 and 2.” Journal of Antimircobial Chemotherapy 71:6-16.

Bohn-Wippert K*Schmidt S*, Runtze A, Zell R, Sauerbrei A (2015)“Resistance testing of clinical herpes simplex virus type 2 isolates collected over 4 decades.”International Journal of Medical Microbiology 305:644-651.