First Name
Last Name
Tufts University
Email ID
United States
Zip code
Department of Biomedical Engineering
Area of Research
Biomedical Engineering
Area of Expertise
nanomedicine, polymer chemistry, drug delivery, targeted cancer therapy
Brief Description of Research Interest:
My research interests mainly focuses on the development of new synthetic materials for the delivery of therapeutic biomacromolecules, such as siRNA, mRNA, protein, and CRISPR genome editing machineries. In my PhD research, I synthesized a series of polypeptide-based nanoparticles for targeted delivery of small molecules, protein, and siRNA. Now, I am interested in using lipid-like nanoparticles to deliver mRNA and CRISPR elements both in vitro and in vivo for disease therapy.
Representative Publications:

Qiu, M.; Ouyang, J.; Wei, Y.; Zhang, J.; Lan, Q.; Deng, C.*; Zhong, Z.*,Selective cell penetration peptide-functionalized envelope-type chimeric lipopepsomes boost systemic RNAi therapy for lung tumors. Adv. Healthcare Mater. 2019, 1900500.

Qiu, M.; Zhang, Z.; Wei, Y.;Sun, H.; Zhang, J.; Meng, F.; Deng, C.*; Zhong, Z.*, Small-sized and robust chimaeric lipopepsomes: A simple and functional platform with high protein loading for targeted intracellular delivery of protein toxin in vivo. Chem. Mater. 201830 (19),6831–6838

Qiu, M.; Wang, X.; Sun, H.;Zhang, J.; Deng, C.*; Zhong, Z.*, Cyclic RGD peptide micelles for enhanced loading and targeted delivery of monomethyl auristatin E. Mol. Pharm. 2018, DOI: 10.1021/acs.molpharmaceut.8b00498.

Qiu, M.; Sun, H.; Meng, F.; Cheng, R.; Zhang, J.; Cheng, L.; Deng,C.*; Zhong,Z.*, Lipopepsomes as a robust nanoplatform for highly efficient encapsulation and tumor-targeteddelivery of doxorubicin hydrochloride. J.Controlled Release 2018, 272, 107-113.

Qiu, M.; Ouyang,J.; Sun, H.; Meng, F.; Cheng, R.; Zhang, J.; Cheng, L.; Lan, Q.; Deng, C.*; Zhong,Z.*,Biodegradable micelles based on poly(ethylene glycol)-b-polylipopeptide copolymer: a robust and versatile nanoplatform for anticancer drug delivery. ACS Appl. Mater. Interfaces 2017, 9, 27587-27595