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Title : Dr.
First Name : YAHUI
Last Name : LAN
University/Institution : Weill cornell medicine
Email ID : yal2011@med.cornell.edu
City : new york
Country : United States
State : New york
Zipcode : 10065
Department : surgery
Company Name :
Area of Research
cardiac development, stem cell, hematopoiesis
Brief Description of Research Interest :

Using human pluripotent stem cells to understand how epigenetic regulation control human cardiac and hematopoietic development. 

In the future, I will dedicate myself to stem cell biology and focus on cardiovascular disease model. With strong background in both hematopoiesis and cardiogenesis fields, as well as multiple models, I am planning to decipher how environmental risk factors affect cardiovascular disease through epigenetic regulation. These studies are not only important for understanding the molecular basis of human cardiovascular development but may also facilitate stem cell-based therapies to regenerate and repair injured cardiac tissues

Representative Publications :

Yahui Lan, Heng Pan, Cheng Li, Kelly M. Banks, Jessica Sam, Bo Ding, Olivier Elemento, Mary Goll, and Todd Evans. TETs Regulate Proepicardial Cell Migration through Extracellular Matrix Organization during Zebrafish Cardiogenesis. Cell Reports 26, 720–732 (2019) https://www.ncbi.nlm.nih.gov/pubmed/30650362

Cheng Li, Yahui Lan, Lianna Schwartz-Orbach, Evgenia Korol, Mamta Tahiliani, Todd Evans, Mary G. Goll. Overlapping requirements for Tet2 and Tet3 in normal development and hematopoietic stem cell emergence. Cell Reports 12, 1133–1143. (2015) https://www.ncbi.nlm.nih.gov/pubmed/26257178

Mendelson, K., Yahui Lan., Hla, T., and Evans, T. Maternal or Zygotic Sphingosine Kinase is Required to Regulate Zebrafish Cardiogenesis. Dev. Dyn 244(8): 948–954. (2015) https://www.ncbi.nlm.nih.gov/pubmed/25997406

Fenghua Zhen*, Yahui Lan*, Bo Yan, Wenqing Zhang, and Zilong Wen, Hemogenic endothelium specification and hematopoietic stem cell maintenance employ distinct Scl isoforms. (*: equal contribution) Development 140, 3977-3985 (2013) https://www.ncbi.nlm.nih.gov/pubmed/24046317

Xiuling Li, Yahui Lan, Jin Xu, Wenqing Zhang and Zilong Wen, SUMO1-activatingenzyme subunit 1 is essential for the survival of hematopoietic stem/progenitorcells in zebrafish. Development 139, 4321-4329 (2012) https://www.ncbi.nlm.nih.gov/pubmed/23132242

Hao Jin, Zhibin Huang, Yali Chi, Mei Wu,Riyang Zhou, Lingfeng Zhao, Jin Xu, Fenghua Zhen, Yahui Lan, Li Li, Wenqing Zhang, Zilong Wen and Yiyue Zhang, c-Mybacts in parallel and cooperatively with Cebp1 to regulate neutrophil maturationin zebrafish. Blood 128:415-426 (2016) https://www.ncbi.nlm.nih.gov/pubmed/27268086

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