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Address 1 : 91 BISHOP ST
Address 2 : 26
Title : Dr.
First Name : POL
University/Institution : Yale University
Email ID : pol.arranzgibert@yale.edu
City : West Haven
Country : United States
State : Connecticut
Zipcode : 06516
Department : Molecular, Cellular and Developmental Biology/ Systems Biology Institute
Company Name :
Area of Research
Synthetic Biology, Chemical Biology
Area of Expertise
Peptide Chemistry, Drug Delivery, Genetic Code Expansion, Bioorthogonal Reactions
Brief Description of Research Interest :

My research interests fall at the interface between chemistry and biology. I have been trained in peptide chemistry during PhD studies, and currently as a postdoc I am developing tools for genetic code expansion. With both, I can combine chemical and biological synthesis of proteins using nonstandard amino acids. I am interested in protein and polymer synthesis, in developing methods for enhancing synthesis quality and yields while at the same time enabling the synthesis of longer proteins with more exotic chemistries. These polymers/proteins may have biotechnological and/or biomedical applications.

Representative Publications :

·         Arranz-Gibert, P.;* Guixer, B.* et al. A MALDI-TOF-based Method for Studying the Transport of BBB Shuttles—Enhancing Sensitivity and Versatility of Cell-Based In Vitro Transport Models. Sci. Rep. 2019

·         Arranz-Gibert, P.;* Prades, R.* et al. HAI Peptide and Backbone Analogs—Validation and Enhancement of Biostability and Bioactivity of BBB Shuttles. Sci. Rep. 2018

·         Arranz-Gibert, P.;* Vanderschuren, K.;* Isaacs, F. Next-Generation Genetic Code Expansion. Curr. Opin. Chem. Biol (Review) 2018

·         Arranz-Gibert, P. et al. Immunosilencing Peptides by Stereochemical Inversion and Sequence Reversal: retro-D-peptides. Sci. Rep. 2018

·         Guillemyn, K.; Starnowska, J.; Lagard, C.; Dyniewicz, J.; Rojewska, E.; Mika, J.; Chung, N. N.; Utard, V.; Kosson, P.; Lipkowski, A. W.; Chevillard, L.; Arranz-Gibert, P. et al. Bifunctional Peptide-Based Opioid Agonist–Nociceptin Antagonist Ligands for Dual Treatment of Acute and Neuropathic Pain. J. Med. Chem. 2016

·         Oller-Salvia, B.; Sánchez-Navarro, M.; Ciudad, S.; Guiu, M.; Arranz-Gibert, P. et al. MiniAp-4: A Venom-Inspired Peptidomimetic for Brain Delivery. Angew. Chem. Int. Ed. 2015

·         Arranz-Gibert, P. et al. Lipid Bilayer Crossing –The Gate of Symmetry. Water-Soluble Phenylproline-Based Blood-Brain Barrier Shuttles. J. Am. Chem. Soc. 2015

·         Malakoutikhah, M.; Guixer, B.; Arranz-Gibert, P.; Teixidó, M.; Giralt, E. ´À la Carte´ Peptide Shuttles: Tools to Increase Their Passage across the Blood-Brain Barrier. ChemMedChem 2014