First Name
Last Name
Meharry Medical College
Email ID
United States
Zip code
Center for AIDS Health Disparities Research
Area of Research
Molecular Virology
Area of Expertise
Brief Description of Research Interest:

My scientific research interests have largely revolved around virus-host interactions. My pre-doctoral research training involved molecular characterization of a DNA virus causing the most devastating viral disease in bananas. In my doctoral research work at Purdue University, I identified and characterized novel virus-host protein interactions that modulate the replication of an RNA virus reported to infect over 600 plant species. During my NIH postdoctoral fellowship at the National Cancer Institute, I researched novel components of the host cellular machinery involved in late stages of HIV-1 replication. In my current position as a postdoctoral research associate at Meharry Medical College, my research interests include key early events leading to HIV-1 integration into host chromosome, role of microRNAs in regulating cellular cofactors of HIV-1, and the impact of drugs of abuse on HIV-1 replication and pathogenesis.

Editor, Vaccines (Topic Board)

GuestEditor, Special Issue "New Insights into HIV-Host interactions", Vaccines

SoLS Interview: Dr. Roger Chalkley (Vanderbilt University): http://societyoflifesciences.org/article-member.aspx?id=2

SoLS Interview: Dr. Joanne Kamens (Addgene): http://societyoflifesciences.org/article-member.aspx?id=1013

Representative Publications:

Balasubramaniam, M., Pandhare, J., Dash, C. 2019. Immune control of HIV. JoLSJournal of Life Sciences 1(1), June 2019:4-36.

Davids, BO., Balasubramaniam, M., Sapp, N., Prakash, P., Ingram, S., Li, M., Craigie, R., Hollis, T., Pandhare, J., Dash, C. 2021. Human three primerepair exonuclease 1 promotes HIV-1 integration by preferentially degrading unprocessed viral DNA. Journal of Virology.10.1128/JVI.00555-21

Jones, B., Balasubramaniam, M., Lebowitz, JJ., Villalta, F., Khoshbouei, H., Dash, C., Pandhare, J. 2021. Activation of proline biosynthesis is critical to maintain glutamate homeostasis during acute methamphetamine exposure. Scientific Reports.11:1422

Chaudhuri, E*., Dash, S*., Balasubramaniam, M*., Holland, OL., Villalta, F., Engelman, A., Pandhare, J., Dash, C. 2020. The HIV-1 capsid binding host factor CPSF6 is post transcriptionally regulated by the cellular microRNA miR-125b. Journal of Biological Chemistry 295(15):5081-5094

*These authors have contributed equally

Balasubramaniam, M., Zhou, J., Addai, A., Martinez, P., Pandhare, J., Aiken, C., Dash, C. 2019. PF74 inhibits HIV-1 integration by altering the composition of the preintegration complex. Journal of Virology.10.1128/JVI.01741-18.

Ysrayl, B., Balasubramaniam, M., Albert, I., Villalta, F., Pandhare, J., Dash, C. 2019. A novel role of prolidase in cocaine-mediated breach in the barrier of brain microvascular endothelial cells. Scientific Reports 9:2567


Balasubramaniam, M., Pandhare, J., Dash, C. 2018. Are microRNAs important players in HIV-1 infection? An update. Viruses 10(3):110.

Novikova, M., Adams, L.,Fontana, J., Gres, A., Balasubramaniam, M., Winkler, D.,Kudchodkar, S.,Soheilian, F., Sarafianos, S., Steven, A., Freed, E. 2018. Identification of a structural element in HIV-1 Gag required for virus particle assembly and maturation. mBio. 9:e01567-18.

Dash S., Balasubramaniam, M., Rana, T.,Godino, A., Peck, E. E., Goodwin, J. S., Calipari, E. S., Villalta, F., Nestler, E. J., Dash, C., Pandhare J. 2017. Poly (ADP-ribose) polymerase-1 (PARP-1) induction by cocaine is post-transcriptionally regulated by miR-125b. eNeuro August 2017, 4(4) e0089-17.2017 1-15


Balasubramaniam, M., Kim, BS., Hutchens-Williams HM.,Loesch-Fries, S. 2014. The photosystem II oxygen evolving complex protein, PsbP,  interacts with the coat protein of Alfalfa mosaic virus and inhibits its replication. Molecular Plant Microbe Interactions 27(10):1107-18.


Balasubramaniam, M., Freed, E. O. 2011. New insights into HIV assembly and trafficking. Physiology 26:236-251.


Balasubramaniam, M., Ibrahim, A., Kim, BS., Loesch-Fries,S. 2006. Arabidopsis thaliana is an asymptomatic host of Alfalfa mosaic virus. Virus Research 121:215-219.