My research focuses on the role of TET1, a major demethylase, in the early mouse embryonic development. I am interested in dissecting the physiological role of TET1 in embryonic and extra-embryonic mouse embryos and the mechanisms by which TET1 regulate cell fate choices during exit from pluripotency. I aim to understand the interplay between the catalytic and non-catalytic activities of TET1.

Lineage-specific functions of TET1 in the postimplantation mouse embryo

Khoueiry R, Sohni A,Thienpont B, Luo X, Van de Velde J, Bartoccetti M, Boeckx B, Zwijsen A, Rao A,Lambrechts D, Koh KP. Nature Genet. 2017 May 15. doi: 10.1038/ng.3868.

PDGFRa+ Cells inEmbryonic Stem Cell Cultures Represent the In Vitro Equivalent of thePre-implantation Primitive Endoderm Precursors.

Antonio Lo Nigro* Anchel de Jaime-Soguero*, Rita Khoueiry, Dong Seong Cho, Giorgia Maria Ferlazzo,Ilaria Perini, Vanesa Abon Escalona, Xabier Lopez Aranguren, Susana M. Chuva deSousa Lopes, Kian Peng Koh, Pier Giulio Conaldi, Wei-Shou Hu, An Zwijsen,Frederic Lluis and Catherine M. Verfaillie. * co-first author. Stem CellReports 2017 Feb 14; 8(2): 318–333.

Dynamic switching of active promoter and enhancer domains regulates Tet1 and Tet2 expressionduring cell state transitions between pluripotency and differentiation.

A. Sohni*, M. Bartoccetti*, R.Khoueiry, L. Spans, J. Vande Velde, L. De Troyer, K. Pulakanti, F.Claessens, S. Rao & K. Peng Koh * co-first author. Mol.Cell. Biol. online 12January 2015, doi:10.1128/MCB.01172-14.

Budding yeast Greatwall and endosulfines control activity and special regulation of PP2A^Cdc55 for timely mitotic progression

Rita Khoueiry*, Maria Angeles Juanes*, Thomas Kupka, Anna Castro, Ingrid Mudrak, EgonOgris, Thierry Lorca1 and Simonetta Piatti. PLoS Genetics, 2013 ;9(7)).* co-first author.

Dynamic CpG methylation of the KCNQ1OT1 gene duringmaturation of human oocytes

RitaKhoueiry, Samira Ibala-Rhomdane, Lionel Méry, ThierryBlachère, Jean-François Guérin, Jacqueline Lornage, Annick Lefèvre.

Journal of Medical Genetics, 2008 Sep;45(9):583-8.

Abnormalmethylation of KCNQ1OT1 and differential methylation of H19 imprinting control  regions in human ICSI embryos

Khoueiry,R.,Ibala-Romdahne S., Al-Khtib M.; Blachère T., Lornage, J., Guérin, J.F.,Lefèvre.
Zygote. 2012 Feb 2:1-10

Analysisof H19 methylation in control and abnormal embryos, sperm and oocytes.

SamiraIbala-Romdhane, M.D., Mohamed Al-Khtib, RitaKhoueiry, Ph.D., Thierry Blachère, Jean-François Guérin, M.D.,Ph.D., Annick  Lefèvre, Ph.D.

Eur J Hum Genet. 2011 Jun8. doi: 10.1038/ejhg.2011.99.

Vitrificationat the Germinal Vesicle stage does not affect the methylation profile of H19and KCNQ1OT1 imprinting centers in human oocytes subsequently matures in vitro

Mohamed Al-Khtib, Astrid Perret, M.D., Rita Khoueiry Ph.D.,Samira Ibala-Romdahne M.D., Thierry Blachère, Jacqueline Lornage, Ph.D., M.D.,Annick Lefèvre, Ph.D. Fertil Steril 2011 Mar 18.

Effetde la maturation in vitro et de la stimulation hormonale sur la mise en placeet le maintien de la méthylation du gène KCNQ1OT1 soumis à empreinte parentale

RitaKhoueiry, Samira Ibala-Rhomdane, Lionel Méry, Thierry Blachère,Jean-François Guérin, Jacqueline Lornage, Annick Lefèvre. Hypothèse June 2010 pages 11-15.