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Title : Dr.
First Name : PHU KHAT
Last Name : NWE
University/Institution : Yale University
Email ID : phukhat.nwe@gmail.com
City : San Diego
Country : United States
State : California
Zipcode : 92122
Department : Chemistry/ Chemical Biology
Company Name :
Area of Research
chemical biology, microbiology & molecular biology
Area of Expertise
Profiling of microbial gut metabolites in relation to G-Protein Coupled Receptors
Brief Description of Research Interest :
My research background falls at the interface of microbiology, molecular biology and chemical biology. My PhD research focused on structurally and functionally profiling small molecule metabolites from gut microbes in relation to the activation of G-Protein Coupled Receptors (GPCRs). In addition, I implemented an biochemical assay platform to study a genotoxic gene cluster implicated in colorectal cancer. Overall, I am interested in the discovery and development of small molecules that have implications in diseases and therapeutics.
Representative Publications :

·        Chen, H.; Nwe, P.-K.; […]; Crawford, J.M.; Palm, N.W. A Forward Chemical Genetic Screen Reveals Gut Microbiota Metabolites that Modulate Host Physiology. Cell, 2019, 177 (5): 1217-1231.

·        Shine, E.E.; Nwe, P.-K.; Crawford, J.M. Chemistry and Enzymology Encoded by the Human Microbiome. Reference Module in Chemistry, Molecular Sciences and Chemical Engineering, Elsevier, 2019,ISBN 9780124095472