Dr. SULOCHAN MALLA
 
 
First Name
SULOCHAN
Last Name
MALLA
University/Institution
National Institute of Health - National Institute on Ageing (NIH/NIA)
Email ID
sulochanthakuri@gmail.com
City
Baltimore
Country
United States
State
Maryland
Zip code
21224
Department
LGG
Area of Research
Molecular Biology and Biochemistry, Genetics and Genomics
Area of Expertise
RNA biology, oxidative stress, gene regulation, RNA damage and quality control process, mRNA co-translational decay, neurodegeneration
Brief Description of Research Interest:
 


Dr. Sulochan Malla is a postdoc fellow in the Laboratory of Genetics and Genomics, National Institute of Health (NIH/NIA). Dr. Malla received his BS degree from SANN International College, Purbanchal University and MS/PhD from Florida Atlantic University. His research interests are on RNA dynamics and their impact on human health and well-being. During his PhD, Dr. Malla studied the molecular basis of RNA damage during oxidative stress and the cellular mechanism of handling oxidatively damaged RNA. RNA oxidation is associated with a large number of human diseases, predominantly age-related neurodegenerative disorders. Mechanistic understanding of RNA oxidation and their quality control process may help to unravel the etiology of many oxidative stress-related human diseases and their therapeutic intervention. 


Dr. Malla has served as an editorial board member of JoLS since Jan 2021.


 
Representative Publications:
 

Szaflarski W, Sowinski M, Leśniczak M, Ojha S, Aulas A, Dave D, Malla S, Anderson P, Ivanov P, and Lyons SM. Modulation of rRNA processing pathways conserves energetic reserves and maintains nucleolar structure during stress.

https://www.biorxiv.org/content/10.1101/2020.08.16.250183v1.full


Ojha S, Malla S, & Lyons SM. (2020). snoRNPs: Functions in Ribosome Biogenesis. Biomolecules, 10(5), 783.

https://doi.org/10.3390/biom10050783


Malla S, Li Z. Functions of conserved domains of human polynucleotide phosphorylase (hPNPase) on RNA oxidation. Insights Biomed Res 3(1): 62-67

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7051052/

 

Kunwar RM, Shrestha K, Malla S, Acharya T, Sementelli A, Kutal D, Bussmann R. Relation of medicinal plants, their use patterns, and availability in the lower Kailash Sacred Landscape, Nepal. Ethnobotany Research and Applications, [Sl.], v. 18, p. 1-14, Mar. 2019. ISSN 1547-3465.

http://www.ethnobotanyjournal.org/index.php/era/article/view/1371/813

 

Li Z, Malla S, Shin B, Li JM. Battle against RNA oxidation: molecular mechanisms for reducing oxidized RNA to protect cells. Wiley Interdiscip Rev RNA. 2014 May-June; 5(3):335-46. doi: 10.1002/wrna.1214. 

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3991771/

 

Malla S, and Li Z. Characterization of mitochondrial and cytoplasmic RNA oxidative damage and involvement of hPNPase in their quality control process. Under review