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Title : Dr.
First Name : RYAN
Last Name : BARNES
University/Institution : University of Pittsburgh
Email ID : ryb22@pitt.edu
City : Pittsburgh
Country : United States
State : Pennsylvania
Zipcode : 15206
Department : Environmental and Occupational Health
Company Name :
Area of Research
Telomere base damage and aging and cancer
Area of Expertise
DNA replication, DNA repair, telomere biology, DNA polymerases
Brief Description of Research Interest :
My current postdoctoral research focuses on the impact oxidative stress has on telomere biology. We have developed a novel tool that specifically induces the common oxidative lesion, 8-oxo-guanine (8oxoG), at telomere specifically. Using this tool in normal cells, I have found telomeric 8oxoG can induce cellular senescence in a p53 and replication-dependent manner. 
My long-term interests include oxidative stress, DNA replication stress, and specialized DNA polymerases.  
Representative Publications :
Elise Fouquerel, Ryan P. Barnes, Shikar Uttam, Simon Watkins, Marcel Bruchez, Patricia L. Opresko. Chronic oxidative guanine base damage at telomeres induces telomere crisis. 2019. Molecular Cell. https://doi.org/10.1016/j.molcel.2019.04.024

Ryan P. Barnes, Wei-Chung Tsao, George L. Moldovan, and Kristin A. Eckert. DNA Polymerase Eta Prevents Tumor Cell Cycle Arrest And Cell Death During Recovery from Replication Stress. 2018. Cancer Research. DOI: 10.1158/0008-5472.CAN-17-3931

Ryan P. Barnes, Suzanne E. Hile, Marietta Y. Lee, and Kristin A. Eckert. DNA Polymerases Eta and Kappa Exchange with the Polymerase Delta Holoenzyme to Complete Common Fragile Site Synthesis. 2017. DNA Repair. https://doi.org/10.1016/j.dnarep.2017.05.006