Brief Description of Research Interest:
My current postdoctoral research focuses on the impact oxidative stress has on telomere biology. We have developed a novel tool that specifically induces the common oxidative lesion, 8-oxo-guanine (8oxoG), at telomere specifically. Using this tool in normal cells, I have found telomeric 8oxoG can induce cellular senescence in a p53 and replication-dependent manner.
My long-term interests include oxidative stress, DNA replication stress, and specialized DNA polymerases.
Representative Publications:
Elise Fouquerel, Ryan P. Barnes, Shikar Uttam, Simon Watkins, Marcel Bruchez, Patricia L. Opresko. Chronic oxidative guanine base damage at telomeres induces telomere crisis. 2019. Molecular Cell. https://doi.org/10.1016/j.molcel.2019.04.024
Ryan P. Barnes, Wei-Chung Tsao, George L. Moldovan, and Kristin A. Eckert. DNA Polymerase Eta Prevents Tumor Cell Cycle Arrest And Cell Death During Recovery from Replication Stress. 2018. Cancer Research. DOI: 10.1158/0008-5472.CAN-17-3931
Ryan P. Barnes, Suzanne E. Hile, Marietta Y. Lee, and Kristin A. Eckert. DNA Polymerases Eta and Kappa Exchange with the Polymerase Delta Holoenzyme to Complete Common Fragile Site Synthesis. 2017. DNA Repair. https://doi.org/10.1016/j.dnarep.2017.05.006