Brief Description of Research Interest:
Representative Publications:
1. Charan M, Das S, Mishra S, Chatterjee N, Varikuti S, Kaul K, et al. Macrophage migration inhibitory factor inhibition as a novel therapeutic approach against triple-negative breast cancer. Cell Death Dis. 2020;11(9):774.
2. Charan M, Verma AK, Hussain S, Misri S, Mishra S, Majumder S, et al. Molecular and Cellular Factors Associated with Racial Disparity in Breast Cancer. Int J Mol Sci. 2020;21(16).
3. #Cam M, #Charan M, #Welker AM, Dravid P, Studebaker AW, Leonard JR, et al. DeltaNp73/ETS2 complex drives glioblastoma pathogenesis- targeting downstream mediators by rebastinib prolongs survival in preclinical models of glioblastoma. (# equally contributed author).Neuro Oncol. 2020;22(3):345-56.
4. Charan M, Dravid P, Cam M, Setty B, Roberts RD, Houghton PJ, et al. Tumor secreted ANGPTL2 facilitates recruitment of neutrophils to the lung to promote lung pre-metastatic niche formation and targeting ANGPTL2 signaling affects metastatic disease. Oncotarget. 2020;11(5):510-22.
5. Charan M, Dravid P, Cam M, Audino A, Gross AC, Arnold MA, et al. GD2-directed CAR-T cells in combination with HGF-targeted neutralizing antibody (AMG102) prevent primary tumor growth and metastasis in Ewing sarcoma. Int J Cancer. 2020;146(11):3184-95.
6. #Charan M, Kushwaha B, Mishra S, and Ganju RK. Epithelial-Mesenchymal Transition (EMT) in Breast Cancer: An Overview. Current Advances in Breast Cancer Research: A Molecular Approach. ISBN: 978-981-14-5142-3. Bentham science publishers (2020). (# Corresponding author).
7. Mishra S, Charan M, Misri S, Ahirwar D, Ganju RK. miRNA Biology in Breast Cancer Progression. In: Suman S, Suman G, Mishra S, editors. Current advances in breast cancer research: A molecular approach. Bentham science publishers; 2020. p. 254–277.
8. Das S, Kaul K, Mishra S, Charan M, Ganju RK. Cannabinoid Signaling in Cancer. Adv Exp Med Biol. 2019;1162:51-61.
9. Charan M, Choudhary HH, Singh N, Sadik M, Siddiqi MI, Mishra S, et al. [Fe-S] cluster assembly in the apicoplast and its indispensability in mosquito stages of the malaria parasite. FEBS J. 2017;284(16):2629-48.
10. Charan M and Habib S. Biosynthesis of [Fe-S] proteins in the apicoplast. (2015). Encyclopedia of Malaria (Springer). DOI 10.1007/978-1-4614-8757-9_44-2.
11. Charan M, Singh N, Kumar B, Srivastava K, Siddiqi MI, Habib S. Sulfur mobilization for Fe-S cluster assembly by the essential SUF pathway in the Plasmodium falciparum apicoplast and its inhibition. Antimicrob Agents Chemother. 2014;58(6):3389-98.
12. Kumar B, Chaubey S, Shah P, Tanveer A, Charan M, Siddiqi MI, et al. Interaction between sulphur mobilisation proteins SufB and SufC: evidence for an iron-sulphur cluster biogenesis pathway in the apicoplast of Plasmodium falciparum. Int J Parasitol. 2011;41(9):991-9.
13. Tanveer A, Allen SM, Jackson KE, Charan M, Ralph SA, Habib S. An FtsH protease is recruited to the mitochondrion of Plasmodium falciparum. PLoS One. 2013;8(9):e74408.