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Title : Dr.
First Name : KRISTINA
Last Name : AMES
University/Institution : Albert Einstein College of Medicine
Email ID : kristina.ames@einsteinmed.org
City : Bronx
Country : United States
State : New york
Zipcode : 10461
Department : Cell Biology
Company Name :
Area of Research
Cell Biology, Autophagy, stem cells
Area of Expertise
PI3K, hematopoietic stem cells, autophagy
Brief Description of Research Interest :

My research interest focuses on the crosstalk between signaling pathways and autophagy process to modulate cellular proliferation. During my doctoral studies, I examined the role of autophagy in stem and progenitor cell proliferation, where I established a non-cell-autonomous role of autophagy in coordinating cell-cycle progression and stem cell proliferation. Currently, as a NIH fellowship recipient, I explore the role of autophagy as one of potential mechanisms that require PI3K signaling during hematopoietic stem cell self-renewal, maintenance and differentiation with the ultimate goal to understand how modulation of autophagy can suppress pathological self-renewal and improve hematologic conditions such as myelodysplasia and leukemia in clinical settings.

Representative Publications :

Ames K. and Melendez A.(2017)."Non-autonomous autophagy in germline stem cell proliferation." Cell Cycle 16(16): 1481-1482.

Ames K., DaCunha DS., Gonzalez B., Konta M., Lin F., Shechter G., Starikov L., Wong S., Bülow HE., Meléndez A. “A non-cell-autonomous role of BEC-1/BECN1/Beclin1 in coordinating cell-cycle progression and stem cell proliferation during germline development.” Curr.Biol. 2017;27:905-13.

Lapierre L. R., Silvestrini M. J., NuñezL., Ames K., Wong S., Le T. T, Hansen M. and Meléndez A.(2013). "Autophagy genes are required for normal lipid levels in C. elegans." Autophagy 9(3): 278-286.

Hemmati S., Sinclair T., Tong M., Bartholdy B., Okabe R. O., Ames K., Ostrodka L., Haque T., Kaur I., Agarwal A., Zhao J.J., Roberts T.M., Gritsman K.,“PI3 kinase alpha and delta promote hematopoietic stem cell activation in response to stress”, JCI Insight, 2019, DOI: 10.1172/jci.insight.125832

Gurska L., Ames K., and Gritsman K. “Signaling Pathways in Leukemic Stem Cells”, book chapter, Adv Exp Med Biol, 2019, DOI: 10.1007/978-981-13-7342-8_1