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Title : Dr.
First Name : VINNY
Last Name : NEGI
University/Institution : University of Pittsburgh
Phone # : 4126482164
Email ID : negiv@pitt.edu
City : Pittsburgh
Country : United States
State : Pennsylvania
Zipcode : 15213
Department : Endocrinology and metabolism
Company Name :
Area of Research
Diabetes, Pulmonary vascular biology, drug development, miRNA
Area of Expertise
Molecular Biology
Brief Description of Research Interest :
My research interest is to develop drug for life threatening diseases with primary focus on discovery of potential therapeutic molecular targets. Currently, my research focuses on epigenetic regulators and its inhibitors in diabetes. Briefly, I am working on BET (bromodomain and extra-terminal domain) proteins -Brd2/4 and histone demethylase proteins (Kdm6a/b) and its associated inhibitors - I-BET and GSK-J4 respectively. These proteins are known to be associated diabetes pathophysiology but their molecular mechanism is not known. Thus, my aim is to explore their mechanism of action that would assist in development of better therapeutics for diabetes. 
In my previous research experience, I worked on re-purposing of small molecular inhibitors for pulmonary hypertension, which is a rare and severe disease. We used a computational pipeline in order to find and validate drug(s) in cellular and rodent model of pulmonary hypertension.
Thus, my major research interest is working towards development of potential therapeutic targets for immediate translational impact.    
Representative Publications :

·       Negi V, Yang J, Speyer G, Pulgarin A, Handen A, Zhao J, Tai YY, Tang Y, Culley MK, Yu Q, Forsythe P, Gorelova A, Watson AM, Aaraj YA, Satoh T, Sembrat J, Provencher S, Vargas SO, Rojas M, Bonnet S, Torrino S,  Bertero T, Wagner BK, Schreiber SL, Mingji Dai9, Ghouleh IA, Kim S, Chan SY. Computational redefinition of therapeutic small molecules from cancer to pulmonary hypertension. Manuscript submitted to Science Translational Medicine.

·     Negi V, Chan S.Y. Non-coding RNAs in pulmonary hypertension: Discerning hierarchies of function in an anarchy of numbers. JCI Insight. 2017 Mar 9;2(5):e91327.

·       Negi V, Paul D, Das S, Bapai P, Singh S, Mukhopadhyay A,Agrawal A, Ghosh B. Altered expression and editing of miRNA-100 regulates iTreg differentiation. Nucleic Acid Research, Sept 2015; 43(16):8057-65.

·       Das S, Kumar M, Negi V, Pattnaik B, Prakash YS, Agrawal A, Ghosh B. MicroRNA-326 regulates pro-fibrotic functions of transforming growth factor-β in pulmonary fibrosis. AJRCMB, May 2014, Vol 50 (5) 882-892.