My current researchinterests are in the area of drug delivery and clinical pharmacometrics. I haveextensive experience in conducting in vitro and in vivo research experiments (preclinicaland clinical) for the developing pharmaceutical products delivering drugs via oral,inhalation or nasal route. I have extensive experience in developing populationpharmacokinetics (POP PK) model from clinical trials using nonlinear mixedeffects approach. My current research projects focused on applying formulation Qualityby Design principles and pharmacometrics models to understand critical formulationproperties influencing clinical PK of inhalation and nasal corticosteroids.In another projects, I used POP PK approach in pediatric study ofanti-infective drugs to describe utilization of alternative novel bloodsampling technique and optimal dosing regimen for the drug.

Published(14):

1.     Bachhav SS, Dighe V, Devarajan PV (2018). Exploring Peyer’s Patch Uptake as a Strategy for Targeted Lung Delivery of Polymeric Rifampicin Nanoparticles. Molecular pharmaceutics 15 (10), 4434-4445.

2.     Bachhav SS, Dighe V, Korak D, Devarajan PV (2017). Rifampicin Lipid-Polymer Hybrid Nanoparticles (LIPOMER) for Enhanced Peyer’s Patch Uptake. International journal of pharmaceutics 532(1), 612-622. [Erratum to this publication:IntJ Pharm. 2017;534(1–2):387–90]   

3.     JindalAB, Bachhav SS, Devarajan PV (2017). In situ hybrid nano drug delivery system of antiretroviral drugfor simultaneous targeting to multiple viral reservoirs: An in vivo proof of concept. International Journal of Pharmaceutics 521(1), 196-203.

4.      Mande PP, Bachhav SS, Devarajan PV (2017). Bioenhanced Advanced Third Generation Solid Dispersion of Tadalafil: Repurposing with improved therapy in pyelonephritis. Asian Journal of Pharmaceutical Sciences, In-press 

5.      Mande PP, Bachhav SS, Devarajan PV (2016). Solid Dispersion of Curcumin as Polymeric Films for Bioenhancement and Improved Therapy of Rheumatoid Arthritis. Pharmaceutical research 33 (8), 1972-1987

6.      Bachhav SS, Bhutada MS, Sharma KS, Patil SD. (2015) .Oleanolic acid prevents increase in blood pressure and nephrotoxicity in nitric oxide dependent type of hypertension in rats. Pharmacognosy research 7 (4),385

7.      Bachhav SS and Kshirsagar NA. (2015). Systematic Review of Drug Utilization Studies and the Use of the Drug Classification System in the WHO SEARO Region. Indian Journal of Medical Research, 142 (2), 120.

8.      Chandy SJ, Michael JS, Veeraraghavan B, Abraham O C, Bachhav SS, Kshirsagar NA (2014). ICMR programme on Antibiotic Stewardship, Prevention of Infection & Control (ASPIC). Indian J Med Res; 139:226-30.

9.      Kshirsagar NA and Bachhav SS. (2013). Nimesulide Controversy: a comparison of European Union and Indian scenario. Int J Risk Saf Med. 2013; 25(4):239-46. 

10.   Kshirsagar NA and Bachhav SS (2013). Comparative regulatory performance on introduction & withdrawal of drugs in India and EU/internationally. Int J Risk Saf Med. 2013; 25(4):235-8.

11.   Kshirsagar NA, Bachhav SS, Kulkarni L, Vijaykumar. (2013).Clinical pharmacology training in India: Status and Need. 45(5): 429–433.

12.   Jadhav MP, Bachhav SS, and Kshirsagar NA (2013),Development of Clinical Pharmacology in India: Perspective of a Young Researcher. Clinical Pharmacology in Drug Development, 2: 201–204. (Guest Editorial)

13.   Bachhav SS, Bhutada MS, Patil SD, Baser B, Chaudhari KB (2012). Effect of Viscum articulatum Burm. (Loranthaceae) inNω-nitro-l-arginine methyl ester induced hypertension and renal dysfunction. Journal of Ethnopharmacology;142 (2): 467-473.

14.   Bachhav SS, Patil SD, Bhutada MS, Surana SJ(2011). Oleanolic acid prevents glucocorticoid-induced hypertension in rats. Phytotherapy Research; 25(10): 1435-39.

Under preparation/submission:

·    Bachhav SS, Sheth P, Sandell D, Svensson M, Bhagwat S, Conti DS, Oguntimein O, Saluja B, Bulitta B, Hochhaus G. Systematic Evaluation of the Effect of Formulation Variables on In-Vitro Performance of Mometasone Furoate Metered Dose Inhalers: A Quality by Design Approach. (Under preparation).

·        Bachhav SS, Dighe V, Mali N, Gogtay NJ, Thatte UM, Devarajan PV. Development and Evaluation of Intranasal Aqua-Triggered In-Situ (ATIS) Gelling Microemulsion of Diazepam: Monitoring Brain Uptake by Microdialysis. (Submitted for publication-Under review)