Type 1 diabetes incidence has increased dramatically over the last 20 years, especially in children less than 5 years of age. We can now predict who will develop diabetes but not yet prevent the disease. Many therapies have been used to target the immune system and the white blood cells involved in killing insulin-producing cells in an attempt to treat and prevent type 1 diabetes. We know that regulatory T cells within the immune system can dampen and prevent the damage caused by destructive cells involved in autoimmunity. Through my research, I am characterizing the regulatory T cells in order to develop a safe and specific therapy to stop the immune destruction of insulin-producing cells in type 1 diabetes patients.

1. Angela M. Mitchell, Erin E. Baschal, Kristen A. McDaniel, Kimber M. Simmons, Laura Pyle, Kathleen Waugh, Andrea K. Steck, Liping Yu, Peter A. Gottlieb, Marian J. Rewers, Maki Nakayama, Aaron W. Michels. Temporal development of T cell receptor repertoires during childhood in health and disease. JCI Insight. 08/2022; DOI: 10.1172/jci.insight.161885. DOI: 10.1172/jci.insight.161885. PMID: 35998036.
2. Angela M. Mitchell and Aaron W. Michels. Self-antigens targeted by regulatory T cells in type 1 diabetes. International Journal of Molecular Sciences. 03/2022; 23(6), 3155 DOI: 10.3390/ijms23063155. PMID: 35328581.
3. Sarah A Greaves, Avinash Ravindran, Radleigh G Santos, Lan Chen, Michael T Falta, Yang Wang, Angela M Mitchell, Shaikh M Atif, Douglas G Mack, Alex N Tinega, Lisa A Maier, Shaodong Dai, Clemencia Pinilla, Johan Grunewald, Andrew P Fontenot. CD4+ T cells in the lungs of acute sarcoidosis patients recognize an Aspergillus nidulans epitope. The journal of Experimental Medicine. 10/2021; 218(10):e20210785. DOI: 10.1084/jem.20210785. PMID: 34410304.
4. Angela M Mitchell, Aimon A Alkanani, Kristen A McDaniel, Laura Pyle, Kathleen Waugh, Andrea Steck, Maki Nakayama, Liping Yu, Peter A Gottlieb, Marian Rewers, Aaron W Michels. T-cell responses to post-translationally modified antigens precede human autoimmune diabetes development. Proceedings of the National Academy of Sciences. 02/2021; 118(6) DOI: 10.1073/pnas.2019129118. PMID: 33542101.
5. Angela M Mitchell and Aaron W Michels. T cell receptor sequencing in autoimmunity. Journal of Life Sciences 12/2020; 2(4): 38-58. DOI: 10.36069/JoLS/20201203. PMID: 33364626.
6. Kimber M Simmons, Angela M Mitchell, Aimon A Alkanani, Kristen A McDaniel, Erin E Baschal, Taylor Armstrong, Laura Pyle, Liping Yu, Aaron W Michels. Failed genetic protection: Type 1 diabetes in the presence of HLA-DQB1*0602. Diabetes 08/2020; 69(8): 1763-1769. DOI: 10.2337/db20-0038. PMID: 32439825.
7. Angela M Mitchell, Ylva Kaiser, Michael T Falta, Daniel J Munson, Laurie G Landry, Anders Eklund, Maki Nakayama, Jill E Slansky, Johan Grunewald, and Andrew P Fontenot. Shared αβ TCR usage in lungs of sarcoidosis patients with Löfgren’s Syndrome. Journal of Immunology 10/2017; 199(7): 2279-2290. DOI: 10.4049/jimmunol.1700570. PMID: 28827283.
8. Angela M Mitchell, Amy E L Stone, Linling Cheng, Kimberly Ballinger, Michael G Edwards, Mark Stoddard, Hui Li, Lucy Golden-Mason, George M Shaw, Salman Khetani, Hugo R Rosen. Transmitted/founder hepatitis C viruses induce cell-type- and genotype-specific differences in innate signaling within the liver. mBio 02/2015; 6(2):e02510-14. DOI:10.1128/mBio.02510-14. PMID: 25714713.
9. Jodi F Hedges, Angela M Mitchell, Kerri Jones, Emily Kimmel, Andrew G Ramstead, Deann T Snyder, Mark A Jutila. Amphotericin B stimulates T and NK cells, and enhances protection from Salmonella infection. Innate Immunity 01/2015; 21(6):598-608. DOI:10.1177/1753425914567692.  PMID: 2560851.
10. Silvia Giugliano, Michael Kriss, Lucy Golden-Mason, Evgenia Dobrinskikh, Amy EL Stone, Alejandro Soto-Gutierrez, Angela Mitchell, Salman R Khetani, Daisuke Yamane, Mark Stoddard, Hui Li, George M Shaw, Michael G Edwards, Stanley M Lemon, Michael Gale Jr, Vijay H Shah, Hugo R Rosen. Hepatitis C virus infection induces autocrine interferon signaling by human liver endothelial cells and release of exosomes, which inhibits viral replication. Gastroenterology 11/2014; 148(2): 392-402. DOI:10.1053/j.gastro.2014.10.040. PMID: 25447848.
11. Amy EL Stone, Angela Mitchell, Jessica Brownell, Daniel J Miklin, Lucy Golden-Mason, Stephen J Polyak, Michael J Gale, Hugo R Rosen. Hepatitis C virus core protein inhibits interferon production by a human plasmacytoid dendritic cell line and dysregulates interferon regulatory factor-7 and signal transducer and activator of transcription (STAT) 1 protein expression. PLoS One 05/2014; 9(5):e95627. DOI:10.1371/journal.pone.0095627. PMID: 2478880.
12. Gary Strobel, Sanjay K Singh, Syed Riyaz-Ul-Hassan, Angela M Mitchell, Brad Geary, Joe Sears. An endophytic/pathogenic Phoma sp. from creosote bush producing biologically active volatile compounds having fuel potential. FEMS Microbiology Letters 07/2011; 320(2):87-94. DOI:10.1111/j.1574-6968.2011.02297.x. PMID: 21535100.
13. Angela M Mitchell, Gary A Strobel, Emily Moore, Richard Robison, Joe Sears. Volatile antimicrobials from Muscodor crispans, a novel endophytic fungus. Microbiology 01/2010; 156(Pt 1):270-277. DOI:10.1099/mic.0.032540-0. PMID: 19797357.
14. Angela M Mitchell, Gary A Strobel, William M Hess, Percy N Vargas, David Ezra. Muscodor crispans, a novel endophyte from Ananas ananassoides in the Bolivian Amazon. Fungal Diversity 07/2008; 31:37-43.