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Title : Dr.
First Name : CHIH HUNG
Last Name : LO
University/Institution : Brigham and Women's Hospital, Harvard Medical School
Email ID : chihhunglo88@gmail.com
City : Boston
Country : United States
State : Massachusetts
Zipcode : 02215
Department : Neurology
Company Name :
Area of Research
Inflammatory and neurodegenerative diseases
Area of Expertise
Membrane protein functions, protein-protein interactions, animal genetics, small molecule drug discovery
Brief Description of Research Interest :
My research interests lie in elucidating the pathogenic mechanisms of neurodegenerative diseases such as Alzheimer’s disease. In particular, I am interested in studying the role of 1) protein misfolding, processing and aggregation, 2) autophagy and metabolic dysfunction, and 3) inflammation/neuroinflammation in neurodegeneration. I am also interested in translational neuroscience and drug discovery to develop novel therapies for these diseases.
Representative Publications :
1.C. H. Lo, E. C. Huber, J. N. Sachs (2020). Conformational states of TNFR1 as a molecular switch for receptor function. Protein Science, In Press, DOI: 10.1002/pro.3829.
2.C. H. Lo, T. M. Schaaf, D. D. Thomas and J. N. Sachs (2020). Fluorescence based TNFR1 biosensor for monitoring of receptor structural and conformational dynamics and discovery of small molecule modulators. Methods in Molecular Biology, In Press.
3.A. R. Braun, E. E. Liao, M. Horvath, M. C. Young, C. H. Lo, R. Brown, M. D. Evans, K. Luk, D. D. Thomas, J. N. Sachs (2020). Potent inhibitors of toxic alpha-synuclein oligomers identified via cellular time-resolved FRET biosensor. BioRxiv, p. 2020.01.09.900845.
4.C. H. Lo, C. K. Lim, Z. Ding, S. P. Wickramasinghe, A. R. Braun, K. H. Ashe, E. Rhoades, D. D. Thomas and J. N. Sachs (2019). Targeting the ensemble of heterogeneous tau oligomers in cells: A novel small molecule screening platform for tauopathies. Alzheimer's & Dementia: The Journal of the Alzheimer's Association 15(11):1489-1502.
5.C. H. Lo, T. M. Schaaf, B. D. Grant, C. K. Lim, P. Bawaskar, C. C. Aldrich, D. D. Thomas and J. N. Sachs (2019). Noncompetitive inhibitors of TNFR1 probe conformational activation states. Science Signaling 12(592): eaav5637.
6.N. Vunnam, C. H. Lo, B. D. Grant, D. D. Thomas and J. N. Sachs (2017). Soluble extracellular domain of death receptor 5 inhibits TRAIL-induced apoptosis by disrupting receptor-receptor interactions. Journal of Molecular Biology 429(19): p.2943-2953.
7.C. H. Lo, N. Vunnam, A. K. Lewis, T. L. Chiu, B. E. Brummel, T. M. Schaaf, B. D. Grant, P. Bawaskar, D. D. Thomas and J. N. Sachs (2017). An innovative high-throughput screening approach for discovery of small molecules that inhibit TNF Receptors. SLAS Discovery 22(8): p.950-961.