My long-term research interests involve the in-depth understanding of the pathogenesis of inflammatory disease. As a graduate student my research work was focused on understanding the signal transduction pathways in cancer cells. I worked on the ubiquitination signaling of cell death regulatory proteins during inflammatory stress. In my postdoctoral studies, I am utilizing human immunology systems and genotype-dependent immune assessments to study polymorphism effects on immune signaling. In addition to biochemical and genetic methods I am also employing in vivo model system to carry out my investigation.

RanjanK, Surolia A and Pathak C.Apoptotic potential of Fas-associated death domain on regulation of cell deathregulatory protein cFLIP and death receptor mediated apoptosis in HEK 293Tcells. J Cell Commun Signal. 2012, 6, 168.

RanjanK, Sharma A, Surolia A and PathakC. Regulation of HA14-1 mediated oxidative stress, toxic response, andautophagy by curcumin to enhance apoptotic activity in human embryonic kidneycells. Biofactors. 2014, 40, 69.

RanjanK and Pathak C. Expression ofcFLIP_L determines the basal interaction of Bcl-2 with Beclin-1and regulates p53 dependent ubiquitination of Beclin-1 during autophagicstress. J Cell Biochem. 2015; 117:1757.

RanjanK and Pathak C. FADDregulates NF-кB activation and promotes ubiquitination of cFLIP_L toinduce apoptosis. Scientific Reports. 2016; 6:22787.

RanjanK and Pathak C. Expression ofFADD and cFLIP_L balances mitochondrial integrity and redoxsignaling to substantiate apoptotic cell death. Mol Cell Biochem, 2016;22:135.

Kumar M, RanjanK, Singh V, Pappachan A, Pathak C and Singh DD. Hydrophilic AcylatedSurface Protein A (HASPA) of Leishmania donovani: Expression,Purification and Biophysico-Chemical Characterization. Protein J.2017; 36:343.