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Postdoctoral, Drug Development @ UCLA
Job Type : Post Doc opening
Category : Drug Development
Department : Integrative Biology and Physiology
Employer : UCLA
Address : UCLA Los Angeles ,California United States
Email : rcrosbie@physci.ucla.edu
Project Start Date : 01/15/2021
Review Date : 01/04/2021
Application Deadline : 12/31/2020
Web Address : www.ibp.ucla.edu/faculty/rachelle-crosbie/

A postdoctoral position in drug development is available at UCLA in the laboratory of Prof. Rachelle H. Crosbie in the Department of Integrative Biology and Physiology at UCLA.  Our research program is focused on cell-extracellular matrix interactions and how loss of muscle cell adhesion causes Duchenne muscular dystrophy, a rare muscle degenerating condition.  Our published work has revealed that overexpression of sarcospan, a small transmembrane protein, ameliorates the skeletal muscle, cardiac, and respiratory dysfunction associated with Duchenne muscular dystrophy.  The postdoctoral project is focused on development of new chemical entities from lead compounds identified in a high throughput screen of small molecules that increase sarcospan expression in muscle cells.  The project will involve testing and developing new analogs as part of the SAR campaign that we are conducting in collaboration with the Drug Discovery Lab in the UCLA Department of Neurology, directed by Prof. Varghese John.  The project will also include in vivo efficacy and safety testing in relevant murine models as well as target identification.  The successful applicant will have a PhD in biology, chemistry, or a related field and have earned first authorship on peer-reviewed publications.  The ability to communicate and work with a diverse team of medicinal chemists and pharmacologists is required.  There are opportunities for training in many areas including biochemical drug-protein target identification, preclinical assessments, drug mechanisms of action, as well as PK and PD studies. Prior postdoctoral fellows have obtain independent academic positions at R1 institutions and Prof. Crosbie will work directly with the applicant to develop many scientific skills including grant writing, communication, and leadership.  Applicants from diverse backgrounds and who value working with diverse individuals are highly encourage to apply. Our research group values inclusion, supportive collaboration, and out of the box thinking.

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