MEMBER PROFILE
| First Name | Jessica |
| Last Name | Rampy |
| University/Institution | Vanderbilt University Medical Center |
| Email ID | [email protected] |
| City | Nashville |
| Country | United States |
| State | Tennessee |
| Zip code | 37232 |
| Department | Pathology, Microbiology, & Immunology/Epidemiology |
| Area of Research | Metabolic Disease and Thyroid Cancer |
| Area of Expertise | thyroid physiology and pathology, cancer epidemiology, metabolic disease |
Brief Description of Research Interest :
Under the mentorship of Dr. Nancy Carrasco, my PhD advisor, I studied the effects of overnutrition on thyroid function using mouse models and discovered several mechanisms by which overnutrition impairs thyroid hormone synthesis and utilization. Additionally, I showed that diet-induced weight loss reversed thyroid damage. I also collaborated with thyroid pathologists to demonstrate translatability of my findings to human thyroid samples.
I am now a postdoctoral research fellow trainee at Vanderbilt University Medical Center under the co-mentorship of thyroid cancer physician scientist, Dr. Vivian Weiss, and cancer epidemiologist, Dr. Martha Shrubsole. I am investigating dietary, metabolic, and environmental risk factors for thyroid cancer, as well as their mechanisms of action. Inspired by my PhD finding that weight loss benefits the thyroid, I am particularly keen to study the effects of GLP-1 receptor agonists, such as Ozempic, on thyroid health.
Representative Publications:
Rampy, J., Torres-Manzo, A.P., Hoffsmith, K., Loberg, M.A., Sheng, Q., Salas-Lucia, F., Bianco, A.C., Arrojo e Drigo, R., Wang, H., Weiss, V.L., Carrasco, N. Overnutrition in Mice Impairs Thyroid Hormone Biosynthesis and Utilization, Causing Hypothyroidism, Despite Remarkable Thyroidal Adaptations. Accepted to J Clin Invest. 2026. [Preprint in bioRxiv. doi:10.1101/2025.03.31.645596.]
Hartmann, H.A., Caroland, K.P., Tumbic, G.W., Rampy, J., Chen, H-C., Chen, S-C., Mannes, C., Wahoski, C.C., Loberg, M.A., Liang, C., Diaz, D., Tigue, M.L., Sheng, Q., Ye, F., Lee, E., Weiss, V.L. PFAS Alter Thyroid Histology and Cellular Signaling in Vitro and in Vivo. J Endocr Soc. 2026;10(2):bvaf210. doi:10.1210/jendso/bvaf210.
Shaklee J., Srivastava K., Brown H., Arriaga E.A., Pierre V.C., van Berlo J.H. Development of a Click-Chemistry Reagent Compatible with Mass Cytometry. Sci Rep. 2018;8(1):6657. doi:10.1038/s41598-018-25000-y