Brief Description of Research Interest :
My research focuses on understanding mitochondrial metabolism, inter-organelle communication, and quality-control mechanisms as central regulators of cellular health in both mammalian and yeast systems. I aim to uncover how mitochondrial dysfunction contributes to a broad range of disorders, including neurodegenerative diseases such as Alzheimer’s and Parkinson’s, metabolic syndromes, and peripheral neuropathies. By investigating the fundamental cell biology of mitochondria, including signaling, organelle crosstalk, and protein homeostasis, my work seeks to elucidate the mechanisms that maintain organelle and cellular homeostasis and identify potential strategies to prevent or treat diseases associated with mitochondrial impairment.
Representative Publications:
Kolitsida P., Saha A., Caliri A., Assali E., Martorell Riera A., Itskanov S., Magana C, Stork B., Shirihai O., Sekler I., Koehler C. and M. van der Bliek A. (2024) Mfn2 induces mitochondrial calcium release by NCLX. Resubmitted to EMBO Reports
BioRxiv Pre-print: https://pubmed.ncbi.nlm.nih.gov/39149365
Kolitsida P., Nolic V., Zhou J., Niemi N. M., Dengjel J., Abeliovich H., (2023) The pyruvate dehydrogenase complex regulates matrix protein phosphorylation and mitophagic selectivity, Life Science Alliance, 6(9) 202302149. https://www.life-science-alliance.org/content/6/9/e202302149
Kolitsida P., Zhou J., Rackiewicz M., Nolic V., Dengjel J., Abeliovich H., (2019) Phosphorylation of mitochondrial matrix proteins regulates their selective mitophagic degradation. Proc Natl Acad Sci USA, 116 (41) 20517-20527, https://www.pnas.org/doi/epdf/10.1073/pnas.1901759116