Brief Description of Research Interest :
Broadly, my research interest is therapeutic development. Upon entering graduate school, I was passionate about synthetic chemistry, particularly the development of small molecules with biological relevance. I chose a Chemical Biology lab for my graduate studies that applied synthetic chemistry to address problems in human health. My research included the design and synthesis of novel inhibitors targeting sulfotransferases – a class of disease-relevant metabolizing enzymes. I also delved into nucleic acid tool development, which led to contributions in establishing DNA aptamers as tools for covalent protein modification and perturbation. Once I received my PhD in Chemistry, I realized I wanted to continue with therapeutic development, but also wanted to gain a more well-rounded view of the translational process. I am currently a Postdoctoral Associate at Magee Women’s Research Institute, where my research focuses on ovarian cancer biology, more specifically, the role of aldehyde dehydrogenase enzymes in chemoresistance.
Representative Publications:
Albright, S.,‡ Cacace, M.,‡ Tivon, Y., Deiters, A. Cell surface labeling and detection of protein tyrosine kinase 7 via covalent aptamers. J. Am. Chem. Soc. 2023 145 (30), 16458-16463. ‡ indicates co-first authors
Cacace, M., Tivon Y., Deiters, A. Methods Enzymol. Protein labeling and crosslinking by covalent aptamers. Methods Enzymol. 2022, 682, 413-428. Invited.
Cook I., Cacace, M., Wang T., Darrah K., Deiters A., Leyh T. Small molecule control of neurotransmitter sulfonation. J. Biol. Chem. 2020, 296, 100094.
Darrah, K., Wang T., Cook, I., Cacace, M., Deiters, A., Leyh, T. Allosteres to regulate neurotransmitter sulfonation J. Biol. Chem. 2019, 294(7), 2293-2301.