MEMBER PROFILE
| First Name | Anh Tuan |
| Last Name | Pham |
| University/Institution | Beth Israel Deaconess Medical Center, Harvard Medical School |
| Email ID | [email protected] |
| City | Boston |
| Country | United States |
| State | Massachusetts |
| Zip code | 02215 |
| Department | Center for Drug Discovery and Translational Resear |
| Area of Research | Chemical Biology, Medicinal Chemistry, Immunology, Oncology |
| Area of Expertise | Chemical Biology, Medicinal Chemistry, Immunology, Oncology |
Brief Description of Research Interest :
I'm interested in utilizing chemical biology tools to gain a deeper understanding of immune signaling pathways. From these tool molecules, I want to apply medicinal chemistry principles to optimize their properties, thus finding promising small molecules for meaningful therapeutic approaches for autoimmune diseases and cancers.
Representative Publications:
Liardo, E.;* Pham, A-T.;* Ghilardi, F. A.; Zhelay, T.; Szteyn, K.; Gandi, N. L.; Ekkati, A.; Koerner, S.; Kozak, J. A.; Sun, L. “Discovery of selective Orai channel blockers bearing an indazole or a pyrazole scaffold” Eur. J. Med. Chem. 2024, 278, 116805.
Cheng, Y.; Pham, A.-T.; Kato, T.; Lim, B.; Moreau, D.; López-Andarias, J.; Zong, L.; Sakai, N.; Matile, S. “Inhibitors of Thiol-Mediated Uptake” Chem. Sci. 2021, 12, 626-631.
Pham, A.-T.; Matile, S. “Peptide Stapling with Anion-π Catalysts” Chem. Asian J. 2020, 15, 1562-1566.
Zhang, X.; Hao, X.; Liu, L.; Pham, A.-T.; López-Andarias, J.; Frontera, A.; Sakai, N.; Matile, S. “Primary Anion-π Catalysis and Autocatalysis” J. Am. Chem. Soc. 2018, 140, 17867-17871.