MEMBER PROFILE
Dr. Srija Chakraborty
| First Name | Srija |
| Last Name | Chakraborty |
| University/Institution | The Ohio State University/Morgridge Institute for Research (present) |
| Email ID | [email protected] |
| City | Madison |
| Country | United States |
| State | Wisconsin |
| Zip code | 53703 |
| Department | Metabolism |
| Area of Research | Using CRISPR screens to map gene-nutrient interactions to investigate novel biomarkers/pathways in different pathologies |
| Area of Expertise | tumor-on-a-chip, Immune cell-stromal cell interactions in solid tumors via 3D constructs |
Brief Description of Research Interest :
As per my PhD training, I have used 3D hydrogel-based tumor constructs and tumor/organ-on-a-chip platforms to study how Natural Killer cells can be leveraged to complement kinase inhibitor treatment in solid tumors like melanoma and colorectal cancer, as well as evaluate how fibroblasts influence these cells when added to the system.
Representative Publications:
Fibroblasts drive differential response in immunotherapy via IL-6 in bioengineered 3D cancer constructs. Srija Chakraborty, Marco Rodriguez, and Aleksander Skardal (under review, Biotechnology and Bioengineering)
Evaluation of natural killer cell tumor homing and effector function in response to CDK4/6 and AURKA inhibition in a melanoma tumor-on-a-chip platform. ( submitted to biorxiv last week)