MEMBER PROFILE

Dr. Rachel Spicer
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First Name Rachel
Last Name Spicer
University/Institution Vanderbilt University Medical Center
Email ID [email protected]
City Nashville
Country United States
State Tennessee
Zip code 37232
Department School of Medicine
Area of Research Neuroscience
Area of Expertise Neurodegeneration

Brief Description of Research Interest :

My PhD research focused on investigating the protein and genetic modifiers of the mutant Huntingtin, as a way of slowing disease progression of Huntington's Disease. Using protein-protein interaction studies, Drosophila melanogaster, and mouse models of Huntington's Disease, I identified two proteins that, when manipulated, could slow disease progression.

Having started my postdoctoral fellowship in January at VUMC, I am investigating the effects of peripheral infection, in the form of sepsis, on persistent cognitive decline and Alzheimer's Disease and Related Dementia. Using Alzheimer's Disease mouse models, I am exploring how inflammatory markers and microglia play a role in these processes.