MEMBER PROFILE
| First Name | Ghaffarian Zavarzadeh |
| Last Name | Parisima |
| University/Institution | East Tennessee State University |
| Email ID | [email protected] |
| City | JOHNSON CITY |
| Country | United States |
| State | Tennessee |
| Zip code | 37614 |
| Department | Biological Sciences |
| Area of Research | Diabetes, Proinsulin misfolding, Proinsulin trafficking, Oxidoreductase enzymes, Protein aggregation. |
| Area of Expertise | Cancer, Neurodegenerative disorders, Biomarker development, Drug repurposing, Bioinfomratics |
Brief Description of Research Interest :
I'm particularly interested in the relationship between non-native proinsulin and diabetes, specifically what causes this misfolding and whether it could be reversible for diabetes treatment. I would like to know which enzymes are not functioning properly in a stressful endoplasmic reticulum environment, leading to protein aggregation, and how these enzymes fail to prevent or improve the situation.
Representative Publications:
Zavarzadeh, P. G., Shalbafan, B., & Abdi, F. (2020). Primary Congenital Glaucoma: Detecting Novel DiseaseCausing Variants Using Whole-Exome Sequencing and Pathway Analysis. Journal of Ophthalmic and Optometric Sciences, 4 (1), 43-59.
Zavarzadeh, P. G., Yaghooti, Y., & Daryabari, S. H. (2020). Genetic Footprints of Human Papilloma Virus in
Ocular Surface Squamous Neoplasia. Journal of Ophthalmic and Optometric Sciences, 4 (3), 54-69.
Zavarzadeh, P. G., Bonyadi, M., & Abedi, Z. (2022). Whole-exome sequencing analysis in a case of primary congenital glaucoma due to the partial uniparental isodisomy. Genomics & Informatics, 20 (3).
Zavarzadeh, P. G., & Abedi, Z. (2023). Novel potential drugs for the treatment of primary open-angle glaucoma using protein-protein interaction network analysis. Genomics & Informatics, 21 (1).