MEMBER PROFILE
| First Name | Anoop |
| Last Name | Arunagiri |
| University/Institution | East Tennessee State University |
| Email ID | [email protected] |
| City | Johnson City |
| Country | United States |
| State | Tennessee |
| Zip code | 37614 |
| Department | Biological Sciences |
| Area of Research | Protein misfolding in diabetes |
| Area of Expertise | Biochemistry, Cell Biology |
Brief Description of Research Interest :
I am Anoop Arunagiri, an Assistant Professor at East Tennessee State University. I am a biochemist doing diabetes research focused on proinsulin misfolding in pancreatic beta cells. Protein folding and aggregation have been my primary areas of interest and expertise. Over the past ten years, I have explored protein aggregates' fascinating characteristics, ranging from biological functions to pathological roles, and biomaterial applications. My long-term goal is to study protein folding problems in degenerative diseases employing biophysical, biochemical, and cell-biological approaches. Access my Google Scholar page here: https://scholar.google.co.in/citations?user=y9ADb94AAAAJ&hl=en.
Representative Publications:
1) Anoop Arunagiri, Maroof Alam, Leena Haataja, et al, Proinsulin Folding and Trafficking Defects Trigger a Common Pathological Disturbance of Endoplasmic Reticulum Homeostasis (2024), Protein Sci. 2024; 33(4): e4949
2) Xiaoxi Xu, Anoop Arunagiri, Maroof Alam, et al, Nutrient-dependent fluctuation in beta cell proinsulin content (2023), J Biol Chem 2023; 299(7):104836
3) Yu-Jie Chen, Jeffrey Knupp, Anoop Arunagiri, et al. PGRMC1 acts as a size-selective cargo receptor to drive ER-phagic clearance of mutant prohormones (2021), Nat Commun 12, 5991 (2021)
4) Maroof Alam, Anoop Arunagiri, Leena Haataja, et al. Predisposition to Proinsulin Misfolding as a Genetic Risk to Diet-Induced Diabetes (2021), Diabetes 2021; 70(11): 2580-2594
5) Anoop Arunagiri, Leena Haataja, Anita Pottekat, et al. Proinsulin Misfolding is an Early Event in the Progression to Type 2 Diabetes (2019), eLife 2019;8:e44532
6) Anoop Arunagiri, Leena Haataja, Corey N Cunningham, et al. Misfolded Proinsulin in the Endoplasmic Reticulum During Development of Beta Cell Failure in Diabetes (2018), Ann N Y Acad Sci, 1418(1):5-19
7) A Anoop, S Ranganathan, BD Dhaked, et al. Elucidating the role of disulfide bond on amyloid formation and fibril reversibility of somatostatin-14: Relevance to its storage and secretion (2014), J Biol Chem, 289(24):16884-16903
8) NN Jha, A Anoop, S Ranganathan, et al. Characterization of amyloid formation by glucagon-like peptides: role of basic residues in heparin-mediated aggregation (2013), Biochemistry, 52 (49):8800–8810