Representative Publications:

·     Varadarajan, J., McWilliams, M.J., and Hughes, S.H. 2013. Treatment with suboptimal doses of Raltegravir leads to aberrant HIV-1 integrations. Proceedings of the National Academy of Sciences, 110 (36):14747-14752

Article Featured in the “In This Issue” section of the Proceedings of the National Academy of Sciences: Zeliadt, N. 2013. Suboptimal doses ofantiretroviral drug induce aberrant HIV-1 integration. Proceedings of the National Academy of Sciences, 110(36): 14505. https://www.pnas.org/content/110/36/14505

Highlighted in the National Cancer Institute-Center for Cancer Research’s “In the Journals” featuring articles reported in top journals. Suboptimal doses of Raltegravir cause aberrant HIV-1 integrations. Hanson, M. 2013 (August). In the Journals-Center for Cancer Research.

·      Varadarajan, J., McWilliams, M.J., Mott, B.T., Thomas, C.J., Smith, S., and Hughes, S.H. 2016. Drug resistant integrase mutants cause aberrant HIV integrations. Retrovirology 13, 71.doi:10.1186/s12977-016-0305-6

·   Varadarajan, J., Guilleminot, J., Saint-Jore-Dupas, C., Piégu, B., Chabouté, M.-E.,Gomord, V., Coolbaugh, R.C., Devic, M., and Delorme, V. 2010. ATR3encodes a diflavin reductase essential for Arabidopsis embryo development. New Phytologist, 187: 67–82.

·     Rankovic, S., Varadarajan, J., Ramalho, R., Aiken, C., and Rousso, I. 2017. Reverse Transcription Mechanically Initiates HIV-1 Capsid Disassembly. Journal of virology, 91(12),e00289-17. doi:10.1128/JVI.00289-17.

·       Jennings, J., Shi,J., Varadarajan, J., Jamieson, P.J., and Aiken, C. 2020. The hostcell metabolite inositol hexakisphosphate promotes efficient endogenous HIV-1reverse transcription by stabilizing the viral capsid. mBio11:e02820-20.