Dr. YAO LIU | Journal of Life Sciences (JoLS)

Dr. YAO LIU

First Name

YAO

Last Name

LIU

University/Institution

Weill Cornell Medicine

Email ID

yal4007@med.cornell.edu

City

New York

Country

United States

State

New york

Zip code

10021

Department

Microbiology and immunology

Area of Research

Mycobacterium tuberculosis, Legionella pneumophila

Area of Expertise

Host-pathogen interaction, bacterial pathogens, bacterial secretion systems, effector proteins

Brief Description of Research Interest:

I got my Ph.D. from Purdue University in December 2018, where I studied the modulation of host cellular pathways (e.g. actin cytoskeleton and ubiquitination) by Legionella pneumophila effector proteins in Dr. Zhao-Qing Luo's lab. Legionella pneumophila, a Gram negative bacterial pathogen, is the causative agent of Legionnaires' disease - a severe pneumonia-like disease.

After graduation, I joined the Dr. Sabine Ehrt's lab at Weill Cornell Medicine as a postdoctoral associate. I am interested in a human bacterial pathogen - Mycobacterium tuberculosis. It is the leading infectious killer in the world, causing ~1.7 million deaths each year. Antibiotic treatment of tuberculosis is available, but relapse of tuberculosis after antibiotic treatment is still a big issue. I am currently studying the host immune mediators that are involved in the relapse of tuberculosis using mouse infection model.

Representative Publications:

Gan, N.^*, Zhen, X.^*, Liu, Y.^*,Xu, X.^*, He, C., Qiu, J., â€¦& Luo, Z. Q. (2019) Regulation ofphosphoribosyl ubiquitination by a calmodulin-dependent 2 glutamylase. Nature. ^* Co-firstauthor.

Akturk, A., Wasilko, D. J., Wu, X., Liu, Y.,Zhang, Y., Qiu, J., ... &Mao, Y. (2018). Mechanism ofphosphoribosyl-ubiquitination mediated by a single Legionella effector. Nature,1.

Liu,Y., Zhu, W., Tan, Y., Nakayasu, E. S., Staiger, C. J., & Luo, Z.Q. (2017). A Legionella effector disrupts hostcytoskeletalstructure by cleaving actin. PLoS pathogens, 13(1), e1006186.

Zhao, J., Beyrakhova, K., Liu, Y., Alvarez,C. P., Bueler, S. A.,Xu, L., ... & Cygler, M. (2017). Molecular basis forthe binding andmodulation of V-ATPase by a bacterial effector protein. PLoSpathogens, 13(6), e1006394.

Qiu, J., Yu, K., Fei,X., Liu, Y., Nakayasu, E. S., Piehowski, P.D., ... &Luo, Z. Q. (2017). A unique deubiquitinase thatdeconjugatesphosphoribosyl-linked protein ubiquitination. Cell research,27(7), 865.

Luo, X., Wasilko, D.J., Liu, Y., Sun, J., Wu, X., Luo, Z. Q., & Mao, Y.(2015). Structure of the Legionellavirulence factor, SidC reveals aunique PI (4) P-specific binding domainessential for its targeting to thebacterial phagosome. PLoS pathogens, 11(6), e1004965.

Liu, Y., Yin, H.,Zeng,W., Liang, Y., Liu, Y., Baba,N., ... & Liu, X. (2011).The effect of the introduction of exogenousstrain AcidithiobacillusthiooxidansA01 on functional gene expression, structure and function ofindigenousconsortium during pyrite bioleaching. Bioresourcetechnology,102(17), 8092-8098.

Liu, Y., Yin, H., Liang, Y., Shen, L., Liu, Y.,Fu, X., ... & Liu, X. (2011). Changes in the composition of an acid minedrainage microbial communityupon successive transfers in medium containinglow-grade copper sulfide. Bioresource technology, 102(20),9388-9394.

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