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Address 1 :
Address 2 :
Title : Dr.
First Name : RAJI
University/Institution : University of Tennessee Health Science Center
Phone # : 5053899451
Email ID : rajismail@gmail.com
City : Memphis
Country : United States
State : Tennessee
Zipcode : 38105
Department : Ophthalmology
Company Name :
Area of Research
Biochemistry and Molecular Biology
Area of Expertise
Retinal cell biology, ER stress signaling
Brief Description of Research Interest :

Raji Rajesh Lenin is doing her third year postdoctoral fellow in the Ophthalmology Department, UTHSC, Memphis.  Her research revolves around endothelial activation and ER stress signaling in diabetic retinopathy (DR), specifically address the regulation of tight junction alterations in endothelial cells. Lenin uses in vitro and in vivo models of endothelial activation and its subsequent impact on visual functions. They recently reported activation of ER stress resulting in endothelial junction protein alterations leading to visual deficits using a mouse model of endothelial-specific tumor necrosisfactor-α (TNF-α)-expressing (tie2-TNF) mice. Their current studies aim to explore in-depth the molecular mechanisms underpinning the ER stress-mediated translational modifications and their connection to vascular permeability defects and compromised vision.

Representative Publications :

Lenin R, Nagy PG, Gentry J, Gangaraju R. Featured Article:Deterioration of visual function mediated by senescence-associated endoplasmic reticulum stress in inflammatory tie2-TNF mice. Experimental biology and medicine (Maywood, N.J.) 2018; 243(12):976-984. PMID: 30114984

Lenin R, Nagy PG, Alli S, Rao VR, Clauss MA, Kompella UB, GangarajuR. Critical role of endoplasmic reticulum stress in chronic endothelial activation-induced visual deficits in tie2-tumor necrosis factor mice. Journal of cellular biochemistry. 2018; 119(10):8460-8471. PMID: 30054947

Lenin R, Thomas SM, Gangaraju R. Endothelial activation and Oxidative stress in neurovascular defects of retina. Current pharmaceutical design. 2019; PMID: 30644342

Elshaer SL, Evans W,Pentecost M, Lenin R, Periasamy R,Jha KA, Alli S, Gentry J, Thomas SM, Sohl N, Gangaraju R. Adipose stem cells and their paracrine factors are therapeutic for early retinal complications of diabetes in the Ins2 Akita mouse. Stem cell research & therapy.2018; 9(1):322. PMID: 30463601

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