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Epigenetic Regulation of Cardiac Development and Disease through DNA Methylation
Yahui Lan and Todd Evans
Kinases: The "Indispensables"of the DNA Damage Response Cascade
Vijay Menon and M. Michael Dcona
Metabolic adaptations to glutamine deprivation in pancreatic cancer
Ying Yang, Mari B. Ishak Gabra, and Mei Kong
JoLS, Journal of Life Sciences, a Postdoc Community Initiative
Nimrat Chatterjee, and Theo van den Broek
Road to HIV cure; from Berlin to London and beyond
Theo van den Broek
Immune Control of HIV
Muthukumar Balasubramaniam, Jui Pandhare, and Chandravanu Dash
Capsid-CPSF6 interaction: Master regulator of nuclear HIV-1 positioning and integration
Vasudevan Achuthan, Jill M. Perreira, Jenny J. Ahn, Abraham L. Brass, Alan N. Engelman
Immunotherapy for hematological malignancies
Shuai Dong, and Irene M Ghobrial
How daily habits help you deal with stress
D. van Lith

Author(s)
Yahui Lan and Todd Evans

Institute
Weill Cornell Medical College
Abstract:

Epigenetic  control  mechanisms play critical roles in organ development and tissue homeostasis. Increasing evidence suggests that cardiac lineage commitment and  cardiovascular disease  are tightly regulated by epigenetic mechanisms, controlling changes in DNA methylation, histone modifications, ATP-dependent chromatin remodeling, and expression levels for non-coding RNAs. This review summarizes our current understanding of epigenetic control mechanisms regulating cardiac development and  disease , particularly focuses on the function of DNA methylation and demethylation through families of DNA methyltransferases and dioxygenases.


Author(s)
Vijay Menon and M. Michael Dcona

Institute
Icahn School of Medicine at Mount Sinai and Virginia Commonwealth University
Abstract:

The human genome is exposed to a gamut of cellular and exogenous insults on a daily basis which needs to be monitored for proper cellular functioning and survival. This surveillance is undertaken by a myriad of protein players that ensure temporal and spatial regulation of cellular homeostasis. Kinases lie at the epicenter of the DNA damage response and exhibit a dynamic functionality, from responding to the damage to regulating the role of other proteins involved in detecting and repairing the damage. Here, we review some of the key kinases involved in DNA damage response pathways and their inhibitors that are either inclinical trials or have received approval for disease treatment.


Author(s)
Ying Yang, Mari B. Ishak Gabra, and Mei Kong

Institute
University of California, Irvine
Abstract:

Pancreatic ductal adenocarcinoma (PDAC), a poorly vascularized malignancy, is one of the most lethal human cancers. Despite using chemotherapy, radiation, and surgery in the treatment of pancreatic cancer, the survival rate remains largely dismal. Several in vivo and patient-based metabolomics analyses revealed that, compared to normal tissues, PDAC tumors are depleted of glutamine, a major metabolic substrate. Yet the mechanisms by which PDAC cells adapt to low glutamine levels are still unclear. Thus, it is imperative to understand the differential metabolic mechanisms in pancreatic cancer. Here, we review the current understanding of metabolic rewiring in pancreatic cancer in response to glutamine deprivation. The elucidation of these adaptive strategies may highlight new opportunities to improve PDAC diagnosis, as well as, shed insight towards novel therapeutic developments.


Author(s)
Nimrat Chatterjee, and Theo van den Broek

Institute
MIT, Boston's Children's Hospital/Harvard Medical School
Address
MIT, Cambridge Massachusetts, Boston Children's Hospital/HMS, Boston, Massachusetts, MA, USA
Abstract:

With great pleasure we welcome you to the first issue of the Journal of Life Sciences (JoLS), a postdoc community initiative. With the generation of this new journal, JoLS has set two major goals. First, the publication of professional peer-reviewed open access international journal within life science. Second, to support the post-doc community by providing an opportunity in gaining experience in reviewing and editing manuscripts and highlighting their research and activities.


Author(s)
Theo van den Broek

Institute
Boston Children’s Hospital, Harvard Medical School
Address
Department of Program in Cellular and Molecular Medicine PCMM, 200 Longwood Ave, Boston,MA 02115. USA
Abstract:

Around 37 million people are living with HIV worldwide, with a million deaths due to HIV in 2017. While only '60% of the infected population are receiving antiretroviral therapy (ART), by taking a combination of drugs suppressing different stage of the HIV lifecycle to lower the viral burden. While the treatment is very effective it does not eliminate HIV from the patient’s body and non-AIDS comorbidities (cardiovascular diseases and cancers) and unrelenting rate of new infections (around 2 million infections per year) have become a major concern and, thus new approaches are needed that no longer continuously suppress HIV but actually cure people.

 
 
     
 
 
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